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Results An EGCGzinc (EGCGZn) nanocomplex was prepared via metalpolyphenol coordination and formulated into a thermosensitive rectal suppository for localized delivery

09850 L 200 B4 L 200 B4

Comparative Antioxidant Profiles Property Glutathione (GSH) Ergothioneine (EGT) Redox activity Very high, dynamic Moderate, stable Chemical stability Low (constantly recycled) Very high Specific transporter No Yes (OCTN1/SLC22A4) Tissue accumulation Limited High (brain, liver, eyes) Mitochondrial protection Indirect (via GPx) Direct DNA protection Mitochondrial (primary) Nuclear and mitochondrial Intestinal degradation Partial Very low Human synthesis Yes (liver) No (dietary only) Mushrooms as the Only Known Source of Both Molecules While glutathione is also found in other foods asparagus, avocado, red meat ergothioneine is found almost exclusively in mushrooms

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Repair Research The natural purpose of BPC in the GI tract is to protect the mucosal barrier from the damaging effects of stomach acid, bile, and other substances essential for digestion and nutrient absorption